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Press Releases. A topical treatment for HPV could provide an economical option," he continued. HPV affects approximately 20 million people in the United States, making it the most common sexually transmitted infection. There are more than types of HPV of which more than 40 are sexually transmitted.
These include two high-risk types, HPV and HPV, which cause the majority of cervical and anogenital cancers, and some portion of head and neck cancers, particularly oral cavity and oropharynx cancers. Cervical cancer is diagnosed in nearly , women each year, killing , annually. In the United States, it was estimated that 12, women in would be diagnosed with cervical cancer, while 10, women and men in the United States get vulvar, vaginal, penile or anal cancers each year.
In addition, some portion of the head and neck cancers in the United States 11, men and women each year is attributable to HPV. In their efforts to inhibit HPV, Baleja and his team zeroed in on the viral protein E2, which controls viral activities including DNA replication and the activation of cancer-causing genes. Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Cell Rep. Lysine acetylation targets protein complexes and co-regulates major cellular functions.
A phase I study of Onyx, an E1B attenuated adenovirus, administered intratumorally to patients with recurrent head and neck cancer. Clin Cancer Res. Experimental therapy of human glioma by means of a genetically engineered virus mutant. Miest TS, Cattaneo R.
New viruses for cancer therapy: meeting clinical needs. Nat Rev. Design and application of oncolytic HSV vectors for glioblastoma therapy. Exp Rev Neurother. Going viral with cancer immunotherapy. Oncolytic viruses and their application to cancer immunotherapy. Cancer Immunol Res. Glioma virus therapies between bench and bedside. Neuro Oncol. Talimogene Laherparepvec improves durable response rate in patients with advanced melanoma.
J Clin Oncol. Epigenetic control of skull morphogenesis by histone deacetylase 8. Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J. Transcription and beyond: the role of mammalian class I lysine deacetylases.
Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis. J Mol Biol. Histone deacetylase activity is required for full transcriptional repression by mSin3A. Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo. Nat Struct Mol Biol. Biochem Biophys Res Commun. Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases. Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alpha.
Cancer Res. Mol Cell Biol. Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes. Nat Immunol. Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med. HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization. J Biol Chem. HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. HDAC6 is a microtubule-associated deacetylase. HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy.
Influenza A virus uses the aggresome processing machinery for host cell entry. Mol Immunol. The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance.https://teccap.cl/includes/map11.php
Key protein for Epstein-Barr virus infection
Functional interaction between class II histone deacetylases and ICP0 of herpes simplex virus type 1. J Virol. ICP0 and the US3 protein kinase of herpes simplex virus 1 independently block histone deacetylation to enable gene expression. Bhattacharyya M, Klein JP. Stat Med. Kawaguchi Y. Us3, a multifunctional protein kinase encoded by herpes simplex virus 1: how does it function in vivo? Hyperphosphorylation of histone deacetylase 2 by alphaherpesvirus US3 kinases. Modulation of the free sphingosine levels in Epstein Barr virus transformed human B lymphocytes by phorbol dibutyrate.
Biochim Biophys Acta. Herpes simplex virus 1 gene expression is accelerated by inhibitors of histone deacetylases in rabbit skin cells infected with a mutant carrying a cDNA copy of the infected-cell protein no 0. Kalamvoki M, Roizman B. Inhibition of the histone demethylase LSD1 blocks alpha-herpesvirus lytic replication and reactivation from latency. Virol J. Sodium butyrate: a chemical inducer of in vivo reactivation of herpes simplex virus type 1 in the ocular mouse model. The herpes simplex virus type 1 latency-associated transcript promoter is activated through Ras and Raf by nerve growth factor and sodium butyrate in PC12 cells.
JCI - Citations to Replication-selective adenoviruses as oncolytic agents
Therapy for latent HIV-1 infection: the role of histone deacetylase inhibitors. Antiviral Chem Chemother. Drug development for recurrent and refractory classical Hodgkin lymphoma. Leuk Lymphoma. Ropero S, Esteller M.
The role of histone deacetylases HDACs in human cancer. Mol Oncol. Central nervous system lupus: a clinical approach to therapy. Histone deacetylase inhibitors augment antitumor efficacy of herpes-based oncolytic viruses. Mol Ther. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells.